Police hunting for Madeleine McCann are said to be focusing on two men and a woman seen with a girl matching her description.
Madeleine: Missing for one weekOfficers have called a news conference for later today and Madeleine's parents were driven away at speed from their apartment.
Sky News crime correspondent Martin Brunt, who is in Portugal, says it appears there has been some significant development.
According to reports, officers have examined CCTV footage showing a girl fitting Madeleine's description with a woman and two men at a service station just a few miles from the village of Praia Da Luz, on the road towards Spain.
The Portuguese newspaper, 24 Horas, said the woman was in her 40s, blonde and appeared foreign.
Martin Brunt said police have shown a still from the CCTV to a British tourist who confirmed it showed a man he had to chase off from photographing his daughter.
Kate McCann at the service"Things are happening, they could be important, there could be a big development," he said.
Earlier a special service was held in the village church at Praia Da Luz in Portugal to mark one week since Madeleine McCann was abducted.
The three-year-old's mother, Kate, repeatedly broke down in tears and had to be supported by a friend as she listened to prayers for Madeleine's safe return.
A small picture of the child hung next to the altar and many of the worshippers cried during the service.
The priest, who was British, said: "They are empty and in despair, but Christ knows where Kate and Gerry McCann are, he knows where Madeleine's grand parents are."
The strain of the last seven days was plain to see on Kate McCann's face as she accepted the sacraments.
The email posterFriends of the McCann family have also arranged a service in Merseyside tonight to pray for the little girl's safe return.
The service will be led by Father Paul Seddon, who married the McCanns and baptised Madeleine.
And Everton FC has released a picture of her in a club shirt.
Captain Phil Neville said everyone was "praying for Madeleine's safe return."
A poster campaign has also been launched by Madeleine's family.
More than 23,000 copies of the poster have been downloaded from the Sky News website and the family have now made it available in French and Spanish.
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